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Search Results for " matrix metalloproteinases "

57

抑制剂 & 化合物

29

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T5361	T-26c	MMP	Proteases/Proteasome
	T-26c 是高效的、选择性的基质金属蛋白酶-13 抑制剂，IC50=6.75 pM。
T14978	CL-82198	MMP	Proteases/Proteasome
	CL-82198 是 MMP-13选择性抑制剂。它能够与 MMP-13 的整个 S1' 口袋结合，这是其对 MMP-13 选择性和对其他 MMP 缺乏抑制活性的基础。它可用于研究骨关节炎。
T4783	JNJ0966	MMP	Proteases/Proteasome
	JNJ0966 是高选择性 MMP-9酶原抑制剂，其 IC50=440 nM。
T16966	S 3304	MMP	Proteases/Proteasome
	S 3304 是一种新型的基质金属蛋白酶抑制剂，能够特异的抑制MMP-2和MMP-9的活性。
T8961	GW280264X Carbamic acid	MMP	Proteases/Proteasome
	GW280264X (Carbamic acid) 是一种 ADAM10/TACE (ADAM17)金属蛋白酶抑制剂。它有效阻断 TACE (ADAM17)和 ADAM10的 IC50分别为 8.0 nM 和 11.5 nM。其中ADAM10/17 能够调节胶质母细胞瘤起始细胞的免疫原性。
T2009	SB-3CT	MMP	Proteases/Proteasome
	SB-3CT 是一种可透过血脑屏障的、竞争性的金属蛋白酶MMP-2和MMP-9抑制剂，Ki 分别为 13.9 nM、600 nM。他对明胶酶具有高选择性。它具有神经保护和抗癌作用。
T16124	MMP13-IN-3	MMP	Proteases/Proteasome
	MMP13-IN-3 是口服有效的MMP-13选择性抑制剂，IC50为 1 nM，比其他 MMP 的选择性高 1000倍多。MMP13-IN-3在用于骨关节炎方面有研究的价值。
T5983	o-Phenanthroline 1,10-菲罗啉,1,10-Phenanthroline	MMP; Others	Others; Proteases/Proteasome
	o-Phenanthroline (1,10-Phenanthroline) 是一种金属螯合剂，能够与 Fe2+形成红色螯合物，在 510 nm 处最大吸收，可防止链脲佐菌素诱导染色体畸变。它也是一种MMP 的抑制剂。
T6011	Batimastat 巴马司他,BB94	MMP	Proteases/Proteasome
	Batimastat (BB94) 是广谱MMP 抑制剂，能够抑制MMP-1 (IC50:3 nM)，MMP-2 (IC50:4 nM)，MMP-9 (IC50:4 nM)，MMP-7 (IC50:6 nM) 和 MMP-3 (IC50:20 nM)。
T5416	T-5224	MMP	Proteases/Proteasome
	T-5224 是选择性的转录因子c-Fos/activator protein (AP)-1抑制剂，具有抗炎作用，能够特异性抑制 c-Fos/c-Jun 的 DNA 结合活性，但对其他转录因子的结合活性无影响。它抑制 IL-1β 诱导的 Mmp-3、Mmp-13、Adamts-5 转录上调。
T22115	SM-7368	NF-κB	NF-κB
	NF-κB Activation Inhibitor III 是一种NF-kB 抑制剂，抑制 TNF-α 诱导的MMP-9上调，靶向抑制下游的MAPK p38，可用于靶向 TNF-α 介导的肿瘤侵袭和转移的化疗研究。
T14322	ARP-100 MMP-2 Inhibitor III	MMP	Proteases/Proteasome
	ARP-100 (MMP-2 Inhibitor III) 是选择性基质金属蛋白酶MMP-2抑制剂 (IC50=12 nM)。它对 MMP-1 (>50 μM)，MMP-3 (4.5 μM)，MMP-7 (>50 μM) 和MMP-9 (0.2 μM) 的抑制活性较小。它与 MMP-2 的 S1＇口袋相互作用，并在体外对基质胶的侵袭模型中显示抗侵袭特性。
T1891	NSC 405020	MMP	Proteases/Proteasome
	NSC 405020 是一种 MT1-MMP 的非催化抑制剂，可特异地靶向 MT1-MMP 的 PEX 结构域，不会抑制 MT1-MMP 和 MMP-2的催化活性。
T2743	Ilomastat Galardin,GM6001,伊洛马司他	MMP	Proteases/Proteasome
	Ilomastat (GM6001) 是广谱的基质金属蛋白酶 (MMP) 抑制剂，可抑制 MMP 的活性，IC50值分别为 1.5 nM (MMP-1)，1.1 nM (MMP-2)，1.9 nM (MMP-3)，0.5 nM (MMP-9)，对人皮肤成纤维细胞胶原酶 (MMP-1) 的Ki=为 0.4 nM。
T8310	MMP-9-IN-1	MMP	Proteases/Proteasome
	MMP-9-IN-1 是特异性的基质金属蛋白酶-9 抑制剂，选择性靶向 MMP-9 的血红素域，对其他 MMP 无影响。
T7522	GI254023X GI 254023X	MMP; Immunology/Inflammation related	Immunology/Inflammation; Proteases/Proteasome
	GI254023X 是MMP9和ADAM10抑制剂，它们的IC50s 分别为 2.5 和 5.3 nM。
T4282	S-methyl-KE-298	MMP; Drug Metabolite	Metabolism; Proteases/Proteasome
	S-methyl-KE-298 是 KE-298 的活性代谢物。KE-298 抑制类风湿关节炎滑膜细胞产生基质金属蛋白酶。
T21806	HNHA	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	HNHA 是组蛋白去乙酰化酶抑制剂。它通过 p21诱导将细胞周期阻滞在 G1/S 期，抑制肿瘤生长及肿瘤新生血管形成。HNHA 可能是一种有效的抗乳腺癌药物。
T0407	Edaravone 依达拉奉右莰醇,依达拉奉,MCI-186	Apoptosis; MMP; Free radical scavengers	Apoptosis; oxidation-reduction; Proteases/Proteasome
	Edaravone (MCI-186) 是一种新型自由基清除剂，能够抑制大鼠与 MMP-9有关的脑出血。
T15574	Incyclinide COL-3,CMT-3	MMP	Proteases/Proteasome
	Incyclinide (COL-3) 是一种基质金属蛋白酶 (MMP) 抑制剂，能够诱导细胞外基质降解，抑制血管生成，肿瘤生长和侵袭以及转移。
T7459	Abametapir 5 5'-二甲基-2,2-联吡啶,HA-44,BRN 0123183	MMP; Others; Parasite	Microbiology/Virology; Others; Proteases/Proteasome
	Abametapir (BRN 0123183) 是一种金属蛋白酶抑制剂，能够靶向对卵孵化和虱子发育至关重要的金属蛋白酶。
T6885	Marimastat BB2516,马立马司他,KB-R8898,TA2516	MMP	Proteases/Proteasome
	Marimastat (BB2516) 是一种血管生成和转移抑制剂，限制血管的生长和生成。它是一种广谱的，具有口服活性的MMPs 抑制剂，有效抑制 MMP-9 , MMP-1, MMP-2, MMP-14, MMP-7，用于癌症的研究。
T7449	o-Phenanthroline monohydrate Phenanthroline monohydrate,1, 10-Phenanthroline monohydrate,邻菲罗啉	MMP	Proteases/Proteasome
	o-Phenanthroline monohydrate (1, 10-Phenanthroline monohydrate) 是一种金属螯合剂，能够与 Fe2+形成红色螯合物，λmax为 510 nm，可防止链脲佐菌素诱导染色体畸变。它也是一种 MMP 的抑制剂。
T6542	Imidapril hydrochloride Novaloc,Imidapril HCl,盐酸咪达普利,Tanapril,TA-6366	RAAS	Endocrinology/Hormones
	Imidapril hydrochloride (Tanapril) 是一种血管紧张素转换酶 (ACE) 抑制剂，具有抗高血压活性。
T5863	Indinavir sulfate L735524 sulfate,MK-639 sulfate,硫酸茚地那韦	SARS-CoV; HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Indinavir sulfate (L735524 sulfate) 是一种 HIV 蛋白酶抑制剂。它抑制 HIV-1 蛋白酶，IC50 值为 0.41 nM，Ki 值为 0.24 nM。它也是SARS-CoV 3CLpro 抑制剂，IC50为 1.71 μM。
T6009	TAPI1 TAPI 1,TAPI,TAPI-1	MMP	Proteases/Proteasome
	TAPI1 (TAPI) 是一种 ADAM17/TACE 抑制剂，可抑制细胞因子受体的脱落。
T1140	Doxycycline hydrochloride Doxylin,盐酸多西环素,Vibramycin,Hyclate	MMP; Antibacterial; Antibiotic	Microbiology/Virology; Proteases/Proteasome
	Doxycycline hydrochloride (Hyclate) 是一种四环素抗生素，是口服有效的广谱金属蛋白酶抑制剂，具有抗菌活性。
TP1741L	Histatin 5 acetate Histatin 5 acetate (115966-68-2 Free base)	MMP	Proteases/Proteasome
	Histatin 5 acetate 抑制宿主基质金属蛋白酶 MMP-2 和 MMP-9 的活性，IC50 分别为 0.57 和 0.25 μM。
T61271	MMP2-IN-3	MMP	Proteases/Proteasome
	MMP2-IN-3是一种有效的基质金属蛋白酶（MMP-2）抑制剂（ IC50 值：31 μM）。MMP2-IN-3 抑制 MMP-9 和 MMP-8 ，其 IC50 分别为 26.6 和 32 μM。
TP1501L	CTTHWGFTLC, CYCLIC acetate(244082-19-7 free base)	MMP	Proteases/Proteasome
	CTTHWGFTLC, CYCLIC acetate(244082-19-7 free base) 是基质金属蛋白酶 (MMP)-2 和 MMP-9 的抑制剂。它也被称为IV 型胶原酶或明胶酶。明胶酶是癌症治疗干预的潜在靶点，这些酶的抑制剂可以防止肿瘤进展。
T22962	Mca-Pro-Leu-NH2	Others	Others
	Substrate of matrix metalloproteinases assay
T69503	ABT-518
	ABT-518 is an inhibitor of matrix metalloproteinases, which are associated with tumor growth and development of metastasis.
T26104	Ro 28-2653 Ro 28 2653,Ro-28-2653,Ro282653
	Ro 28-2653 is a matrix-metalloproteinases (MMPs) inhibitor with high selectivity for MMP2, MMP9 and membrane type 1-MMP.
T24431	Matlystatin A
	Matlystatin A is an inhibitor of aminopeptidase. It shows multiple inhibitory activities against both aminopeptidase N and matrix metalloproteinases.
T70052	S-3304
	S-3304 is a n orally-agent agent with potential antineoplastic activity. S-3304 inhibits matrix metalloproteinases (MMPs), thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis.
T27507	GW-3333 GW 3333,GW3333
	GW-3333 is an matrix metalloproteinase inhibitor. It is also a tumor necrosis factor-alpha (TNF)-Converting Enzyme (TACE) inhibitor. The efficacy of GW3333 suggests that dual inhibitors of matrix metalloproteinases and TACE may prove therapeutic as antiar
T25055	alpha-RA-F α RA F,alphaRAF,α-RA-F,αRAF
	alpha-RA-F can modulate collagen synthesis and matrix metalloproteinases (MMPs) expression levels by boosting collagen synthesis and reducing MMPs expression levels in human fibroblasts without cytotoxicity.
T13357	XL-784 free base	Others	Others
	XL-784 free base is a selective inhibitor of matrix metalloproteinases (MMP), (IC50s of ~1900, 0.81, 120, 10.8, 18, 0.56 nM for MMP-1,MMP-2,MMP-3,MMP-8,MMP-9,MMP-13,respectively).
T16986	Tanomastat BAY 12-9566	MMP	Proteases/Proteasome
	Tanomastat is an orally bioavailable and non-peptidic biphenyl matrix metalloproteinases inhibitor. For MMP-2, MMP-3, MMP-9, MMP-13 the Ki values are 11, 143, 301, and 1470 nM respectively.
T13358	XL-784	MMP	Proteases/Proteasome
	XL-784 is a selective inhibitor of matrix metalloproteinases (MMP)(IC50s of ~1900, 0.81, 120, 10.8, 18, 0.56 nM for MMP-1,MMP-2,MMP-3,MMP-8,MMP-9,MMP-13,respectively).
T71420	RO314724
	RO314724 is a HDAC inhibitor. RO314724 is also a a reversible, tightly binding, MMP inhibitor with a Ki of 26 nm. Matrix metalloproteinases (MMPs) belong to the key enzymes of the proteolytic destruction of cartilage matrix during chronic rheumatic diseases. Ro314724 displayed MMP-proteoglycanase inhibitory activity both in vitro and ex vivo and proved to be not harmful to the morphology, viability and proteoglycan biosynthesis of bovine articular cartilage explants.
TP1741	Histatin 5
	Histatin 5 inhibits the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC50s of 0.57 and 0.25 μM, respectively. Histatin 5 is a human basic salivary peptide with strong fungicidal properties in vitro.
T75755	Histatin 5 TFA
	Histatin 5 TFA 抑制宿主基质金属蛋白酶MMP-2和MMP-9活性，IC50s 分别为 0.57 和 0.25 μM。
T76017	CTTHWGFTLC, CYCLIC TFA
	CTTHWGFTLC, CYCLIC TFA 是一种基质金属蛋白酶 MMP-2和MMP-9的环肽抑制剂。对MMP-9的IC50约为 8 μM。
T81728	Myristoyl tetrapeptide Ala-Ala-Pro-Val
	Myristoyl tetrapeptide Ala-Ala-Pro-Val 是具有生物活性的四肽，能够促进ECM蛋白的表达以及抑制金属蛋白酶（MMP）的表达。
T14312	Apratastat	MMP; TNF	Apoptosis; Proteases/Proteasome
	Apratastat is an orally active, potent, and reversible dual inhibitor of tumor necrosis factor-α converting enzyme (TACE) and matrix metalloproteinases (MMPs) and it also can potently inhibit the release of TNF-α in vitro, ex vivo, and in vivo with IC50s of 144 ng/mL in vitro and 81.7 ng/mL ex vivo, respectively[1].
T21814	ONO 4817
	ONO-4817 是一种广谱基质金属蛋白酶 (MMP) 抑制剂。抑制基质金属蛋白酶 (MMP) 有望抑制动脉粥样硬化新内膜增殖，从而限制动脉粥样硬化斑块的进展。ONO-4817 抑制实验性高脂血症兔主动脉内膜增生的发展。
TP1501	CTTHWGFTLC, CYCLIC
	This cyclic CTT Gelatinase Inhibitor peptide is an inhibitor for matrix metalloproteinases (MMP)-2 and MMP-9. It is also called type IV collagenase or gelatinase. Gelatinases are potential targets of therapeutic intervention in cancer, and inhibitors of t
TP1446	Histatin 5 (TFA)(115966-68-2,free) Histatin 5 (TFA)	MMP	Proteases/Proteasome
	Histatin 5 (TFA)(115966-68-2,free) (Histatin 5 (TFA)) 抑制宿主基质金属蛋白酶 MMP-2 和 MMP-9 的活性，IC50 分别为 0.57 和 0.25 μM。
T60551	MMP2-IN-2
	MMP2-IN-2 (化合物 42) 是一种有效且选择性的MMP-2(基质金属蛋白酶)抑制剂，其IC50值为 4.2 μM。它对MMP-13、MMP-9和MMP-8也具有抑制活性，IC50值分别为 12、23.3 和 25 μM。

化合物

Cat.No: T5361

Target: MMP

Cat.No: T14978

Target: MMP

Cat.No: T4783

Target: MMP

Cat.No: T16966

Target: MMP

Cat.No: T8961

Synonym: Carbamic acid

Target: MMP

Cat.No: T2009

Target: MMP

Cat.No: T16124

Target: MMP

o-Phenanthroline

Cat.No: T5983

Synonym: 1,10-菲罗啉,1,10-Phenanthroline

Target: MMP, Others

Cat.No: T6011

Synonym: 巴马司他,BB94

Target: MMP

Cat.No: T5416

Target: MMP

Cat.No: T22115

Target: NF-κB

Cat.No: T14322

Synonym: MMP-2 Inhibitor III

Target: MMP

Cat.No: T1891

Target: MMP

Cat.No: T2743

Synonym: Galardin,GM6001,伊洛马司他

Target: MMP

Cat.No: T8310

Target: MMP

Cat.No: T7522

Synonym: GI 254023X

Target: MMP, Immunology/Inflammation related

S-methyl-KE-298

Cat.No: T4282

Target: MMP, Drug Metabolite

Cat.No: T21806

Target: HDAC

Cat.No: T0407

Synonym: 依达拉奉右莰醇,依达拉奉,MCI-186

Target: Apoptosis, MMP, Free radical scavengers

Cat.No: T15574

Synonym: COL-3,CMT-3

Target: MMP

Cat.No: T7459

Synonym: 5 5'-二甲基-2,2-联吡啶,HA-44,BRN 0123183

Target: MMP, Others, Parasite

Cat.No: T6885

Synonym: BB2516,马立马司他,KB-R8898,TA2516

Target: MMP

o-Phenanthroline monohydrate

Cat.No: T7449

Synonym: Phenanthroline monohydrate,1, 10-Phenanthroline monohydrate,邻菲罗啉

Target: MMP

Imidapril hydrochloride

Cat.No: T6542

Synonym: Novaloc,Imidapril HCl,盐酸咪达普利,Tanapril,TA-6366

Target: RAAS

Indinavir sulfate

Cat.No: T5863

Synonym: L735524 sulfate,MK-639 sulfate,硫酸茚地那韦

Target: SARS-CoV, HIV Protease

Cat.No: T6009

Synonym: TAPI 1,TAPI,TAPI-1

Target: MMP

Doxycycline hydrochloride

Cat.No: T1140

Synonym: Doxylin,盐酸多西环素,Vibramycin,Hyclate

Target: MMP, Antibacterial, Antibiotic

Histatin 5 acetate

Cat.No: TP1741L

Synonym: Histatin 5 acetate (115966-68-2 Free base)

Target: MMP

Cat.No: T61271

Target: MMP

CTTHWGFTLC, CYCLIC acetate(244082-19-7 free base)

Cat.No: TP1501L

Target: MMP

Mca-Pro-Leu-NH2

Cat.No: T22962

Target: Others

Cat.No: T69503

Cat.No: T26104

Synonym: Ro 28 2653,Ro-28-2653,Ro282653

Cat.No: T24431

Cat.No: T70052

Cat.No: T27507

Synonym: GW 3333,GW3333

Cat.No: T25055

Synonym: α RA F,alphaRAF,α-RA-F,αRAF

XL-784 free base

Cat.No: T13357

Target: Others

Cat.No: T16986

Synonym: BAY 12-9566

Target: MMP

Cat.No: T13358

Target: MMP

Cat.No: T71420

Cat.No: TP1741

Cat.No: T75755

CTTHWGFTLC, CYCLIC TFA

Cat.No: T76017

Myristoyl tetrapeptide Ala-Ala-Pro-Val

Cat.No: T81728

Cat.No: T14312

Target: MMP, TNF

Cat.No: T21814

CTTHWGFTLC, CYCLIC

Cat.No: TP1501

Histatin 5 (TFA)(115966-68-2,free)

Cat.No: TP1446

Synonym: Histatin 5 (TFA)

Target: MMP

Cat.No: T60551

Cat. No.	Product Name	Target	Signaling Pathways
T3414	Morroniside 莫诺苷,奎宁树	Apoptosis; MMP; Pyroptosis	Apoptosis; Immunology/Inflammation; Proteases/Proteasome
	Morroniside 通过抑制神经元凋亡和 MMP9/2 的表达从而发挥神经保护作用，可作为 db/db 小鼠肝脏炎症反应和脂质代谢的调节剂。它通过抑制高血糖和氧化应激表现出对糖尿病肾损伤和人脐静脉内皮细胞的保护作用。
T2993	Cordycepin 3'-Deoxyadenosine,虫草素	MMP; TNF; Antibacterial; Antibiotic; Autophagy	Apoptosis; Autophagy; Microbiology/Virology; Proteases/Proteasome
	Cordycepin (3'-Deoxyadenosine) 是一种核苷衍生物，在类风湿性关节炎滑膜成纤维细胞中，剂量依赖性抑制 IL-1β 诱导的 MMP-1和 MMP-3表达。它也抑制细菌的腺苷激酶从而抗结核分枝杆菌。
T4115	Auraptene 橙皮油内酯,7-geranyloxycoumarin,橙皮油素	MMP; BACE	Neuroscience; Proteases/Proteasome
	Auraptene 是一种丰富的天然香叶氧基香豆素。它能够抑制基质金属蛋白酶 2 以及关键炎症因子，包括 IL-6，IL-8 和趋化因子 (C-C 基序) 配体-5 (CCL5）的分泌。
TN1879	Lucideric acid A Lucidenic acid A,赤芝酸A	MMP; p38 MAPK; JNK	MAPK; Proteases/Proteasome
	Lucideric acid A (Lucidenic acid A) 是分离自灵芝的天然产物，可抑制 PMA 诱导的MMP-9活性，具有抵抗肝癌细胞侵袭的作用。
T8259	Doxycycline monohydrate 水合强力霉素,强力霉素一水物	MMP; Antibacterial; Antibiotic; Parasite	Microbiology/Virology; Proteases/Proteasome
	Doxycycline monohydrate 是一种四环素抗生素，是广谱金属蛋白酶抑制剂，具有抗菌活性。
T2967	Stigmasterol Stigmasterin,beta-Stigmasterol,豆甾醇	MMP; Endogenous Metabolite	Metabolism; Proteases/Proteasome
	Stigmasterol (Stigmasterin) 是一种植物性甾醇，具有抑制胆固醇的特性，此外在风湿性疾病的研究中被评价为抗硬化因子。
T3860	Isoliquiritin apioside	MMP; p38 MAPK; NF-κB	MAPK; NF-κB; Proteases/Proteasome
	Isoliquiritin apioside 可抑制癌细胞和内皮细胞的侵袭和血管生成，显著降低 PMA 诱导的MMP9活性增加，并抑制 PMA 诱导的MAPK 和NF-κB 活化。
T6S0444	Salvianolic acid A 丹酚酸 A,Dan Phenolic Acid A	MMP	Proteases/Proteasome
	Salvianolic acid A (Dan Phenolic Acid A) 能够提高抑制基质金属钛酶 9 和抗炎作用，进而保护血脑屏障。
T2980	Chondroitin sulfate Chonsurid,Chondroitin polysulfate,硫酸软骨素	MMP; Others; Endogenous Metabolite; NO Synthase	Immunology/Inflammation; Metabolism; Others; Proteases/Proteasome
	Chondroitin sulfate (Chonsurid) 是一种糖胺聚糖，被广泛用于骨关节炎的研究。它能够减少炎症介质和凋亡过程，并能够减少炎性细胞因子，iNOS 和MMPs 产生。
T2957	Arctigenin 牛蒡苷元,牛蒡子苷元,(-)-Arctigenin	Apoptosis; MMP; Influenza Virus; Autophagy	Apoptosis; Autophagy; Microbiology/Virology; Proteases/Proteasome
	Arctigenin ((-)-Arctigenin) 是一种存在于牛蒡中的木脂素，具有抗氧化、抗肿瘤、抗炎和抗病毒活性。它可研究代谢紊乱和中枢神经系统功能障碍。
T3767	Polygalacic acid Virgaureagenin G,毛果一枝黄花皂苷元G,远志酸	MMP; AChR; AChE	Neuroscience; Proteases/Proteasome
	Polygalacic acid (Virgaureagenin G) 是一种从远志 Polygala tenuifolia Willd 根中分离出来的三萜，可抑制 MMP 表达。它对认知障碍有显著的神经保护作用，PA 通过抑制乙酰胆碱酯酶活性，增加胆碱乙酰转移酶活性，提高海马和额皮质中的乙酰胆碱水平来提高胆碱能系统反应性。它可以用于骨关节炎相关研究。
T2987	(-)-Epigallocatechin 表没食子儿茶素,(-)-表没食子儿茶素,l-Epigallocatechin,Epigallocatechin,EGC	MMP; Autophagy	Autophagy; Proteases/Proteasome
	(-)-Epigallocatechin (Epigallocatechin) 是绿茶中含量最丰富的黄酮类天然产物，可与未折叠的天然多肽结合，阻止转化为淀粉样蛋白原纤维。
T3S0640	Triolein 三油酸甘油酯,Glycerol trioleate,甘油三油酸酯,Glycerine Trioleate	MMP; Others; Endogenous Metabolite	Metabolism; Others; Proteases/Proteasome
	Glycerol trioleate 是一种对称三酰甘油，可减少MMP-1的上调，具有很强的抗氧化、抗炎特性。
T5S1026	Apigenin-7-glucuronide Apigenin 7-O-glucuronide,芹菜素-7-葡萄糖醛酸	MMP	Proteases/Proteasome
	Apigenin-7-glucuronide (Apigenin 7-O-glucuronide) 能够抑制基质金属蛋白酶的活性，其对 MMP-3 (IC50:12.87 μM)，MMP-8 (IC50:22.39 μM)，MMP-9 (IC50:17.52 μM)，MMP-13 (IC50:0.27 μM)。
T5680	Aloin(mixture of A&B) 芦荟素,葡糖基蒽酮,芦荟大黄素甙,芦荟苷	MMP; IL Receptor; Antibacterial; Antifungal	Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	Aloin (mixture of A&B) 是一种从芦荟中分离出来的蒽醌衍生物。它是刺激性粒细胞基质金属蛋白酶的有效抑制剂。它具有多种生物活性，如抗炎、抗菌、抗真菌、抗氧化、抗肿瘤、抗糖尿病和免疫活性。
T2750	Ginkgolide C 银杏内酯C,BN-52022	MMP; Sirtuin; Endogenous Metabolite; AMPK	Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Ginkgolide C (BN-52022) 是从银杏叶中分离到的一种黄酮类天然产物，可增强体内大鼠的心脏功能，具有减少血小板聚集，改善阿尔兹海默症等作用。
T2973	Astragaloside IV AST-IV,黄芪甲苷IV,AS-IV,黄芪皂苷 IV	MMP; ERK; Estrogen/progestogen Receptor; JNK	Endocrinology/Hormones; MAPK; Proteases/Proteasome
	Astragaloside IV (AS-IV) 是从黄芪中分离得到的一种皂苷，抑制ERK1/2和JNK 激活，在乳腺癌细胞 MDA-MB-231 中，下调(MMP)-2和(MMP)-9的信号通路。
T6S2140	β-Anhydroicaritin Anhydroicaritin,Beta-Anhydroicaritin,脱水淫羊藿素	MMP; Others; TNF; Interleukin	Apoptosis; Immunology/Inflammation; Others; Proteases/Proteasome
	β-Anhydroicaritin 是从乳香提取的一种天然产物，具有重要的生物学和药理学作用，如抗骨质疏松症，雌激素调节和抗肿瘤特性。它改善牙周组织的降解，抑制糖尿病大鼠 TNF-α 和 MMP-3 的合成和分泌。它抑制细胞内 Ca2+的升高，并显著降低 iNOS 蛋白的表达。
T1687	Doxycycline Vibramycin,多西环素,Doxiciclina,Doxytetracycline,Doxycyclinum,强力霉素	MMP; ribosome; Antibacterial; Antibiotic; Parasite	Microbiology/Virology; Proteases/Proteasome
	Doxycycline (Doxiciclina) 属于四环素类抗生素，是一种广谱的金属蛋白酶 (MMP) 抑制剂，具有口服活性。Doxycycline 具有抗菌活性和抗肿瘤活性。
T3850	Luteolin 7-O-glucuronide Luteolin-7-glucuronide,木犀草素-7-O-葡萄糖醛酸苷	MMP	Proteases/Proteasome
	Luteolin 7-O-glucuronide (Luteolin-7-glucuronide) 是一种自由基清除剂，能够抑制基质金属蛋白酶的活性，其对 MMP-1，MMP-3，MMP-8，MMP-9，MMP-13的IC50值分别为 17.63，7.99，11.42，12.85，0.03 μM。
T5S0045	Isofraxidin 6,8-Dimethoxyumbelliferone,异秦皮啶,Phytodolor,异嗪皮啶	MMP; ERK; p38 MAPK; TLR; COX	Immunology/Inflammation; MAPK; Neuroscience; Proteases/Proteasome
	Isofraxidin (Phytodolor) 是来自刺五加的香豆素成分，抑制MMP-7表达和人肝癌细胞侵袭。它作用于肝癌细胞，抑制ERK1/2磷酸化。它减弱iNOS 和COX-2表达，还抑制TLR4/髓样分化蛋白 2 复合物的形成。
T4S21320	ISOGINKGETIN 异银杏素,4',4'''-Dimethylamentoflavone,异银杏双黄酮	MMP; Others	Others; Proteases/Proteasome
	ISOGINKGETIN (4',4'''-Dimethylamentoflavone) 是一种MMP9抑制剂，也是一种Pre-mRNA Splicing 抑制剂。
T3813	20(R)-Ginsenoside Rh2 20(R)-人参皂苷 RH2,(20R)Ginsenoside Rh2,Ginsenoside Rh2,20(R)-人参皂苷Rh2	Apoptosis; MMP; HSV	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	20(R)-Ginsenoside Rh2 (Ginsenoside Rh2) 是人参皂苷 Rh2 的次要立体异构体，具有基质金属蛋白酶抑制作用。它有抗癌、抗炎和抗氧化活性。
T1205	Chloramphenicol Chlornitromycin,Levomycetin,Chloromycetin,氯霉素	ribosome; HIF/HIF Prolyl-Hydroxylase; Antibacterial; Antibiotic	Chromatin/Epigenetic; Metabolism; Microbiology/Virology
	Chloramphenicol (Chloromycetin) 是一种广谱抗生素，有效抑制细菌蛋白质生物合成。它主要作用于细菌 70S 核糖体的 50S 亚基，对肽基转移酶有活性，抑制肽键的形成。
T1687L	Doxycycline (hyclate) Doxycycline hydrochloride hemiethanolate hemihydrate,盐酸强力霉素,WC2031,Doxycycline hyclate	MMP; ribosome; Antibacterial; Antibiotic	Microbiology/Virology; Proteases/Proteasome
	Doxycycline hyclate (WC2031) 属于四环素类抗生素，是一种广谱的金属蛋白酶 (MMP) 抑制剂，具有口服活性。Doxycycline hyclate 具有抗菌活性和抗肿瘤活性。
T2769	3-Aminopropionitrile fumarate (2:1) Di-β-aminopropionitrile fumarate,3-Aminopropionitrile fumarate,3-氨基丙腈,β-Aminopropionitrile fumarate,3-Aminopropionitrile fumarate 2:1,Beta-Aminopropionitrile fumarate,β-Ammoniumpropionitrile hemifumarate	Others	Others
	3-Aminopropionitrile fumarate (2:1) (β-Aminopropionitrile fumarate) 是一种能抑制胶原蛋白(collagen)交联的山黧豆素。
TN2697	2,3-Dihydrohinokiflavone	MMP; Parasite; Antifection	Microbiology/Virology; Proteases/Proteasome
	2,3-Dihydrohinokiflavone 是基质金属蛋白酶 (MMP) 基因表达的抑制剂，对利什曼原虫具有很强的活性，IC50 为 1.6 μM。
TN4088	Futoenone	PAFR	GPCR/G Protein
	Futoenone and a series of its derivatives have shown inhibitory activities against matrix metalloproteinases, the molecular modelings of these compounds indicate the preferred binding of the P2' site of the enzymes. Neolignan derivative compounds of the 2,4-diaryl-1,3-dithiolane and futoenone variety exhibit both platelet activating factor receptor(PAF)and 5-lipoxygenase antagonist activity.
TN4592	Murrangatin	IL Receptor; TNF; COX; Prostaglandin Receptor	Apoptosis; GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Murrangatin may be a valuable anti-tumor-promoting agent, it can significantly inhibit Epstein-Barr virus early antigen (EBV-EA) activation, and preserve the high viability of Raji cells, it also exhibits cytotoxicity against cholangiocarcinoma cell line,

天然产物

Cat.No: T3414

Synonym: 莫诺苷,奎宁树

Target: Apoptosis, MMP, Pyroptosis

Cat.No: T2993

Synonym: 3'-Deoxyadenosine,虫草素

Target: MMP, TNF, Antibacterial, Antibiotic, Autophagy

Cat.No: T4115

Synonym: 橙皮油内酯,7-geranyloxycoumarin,橙皮油素

Target: MMP, BACE

Lucideric acid A

Cat.No: TN1879

Synonym: Lucidenic acid A,赤芝酸A

Target: MMP, p38 MAPK, JNK

Doxycycline monohydrate

Cat.No: T8259

Synonym: 水合强力霉素,强力霉素一水物

Target: MMP, Antibacterial, Antibiotic, Parasite

Cat.No: T2967

Synonym: Stigmasterin,beta-Stigmasterol,豆甾醇

Target: MMP, Endogenous Metabolite

Isoliquiritin apioside

Cat.No: T3860

Target: MMP, p38 MAPK, NF-κB

Salvianolic acid A

Cat.No: T6S0444

Synonym: 丹酚酸 A,Dan Phenolic Acid A

Target: MMP

Chondroitin sulfate

Cat.No: T2980

Synonym: Chonsurid,Chondroitin polysulfate,硫酸软骨素

Target: MMP, Others, Endogenous Metabolite, NO Synthase

Cat.No: T2957

Synonym: 牛蒡苷元,牛蒡子苷元,(-)-Arctigenin

Target: Apoptosis, MMP, Influenza Virus, Autophagy

Polygalacic acid

Cat.No: T3767

Synonym: Virgaureagenin G,毛果一枝黄花皂苷元G,远志酸

Target: MMP, AChR, AChE

(-)-Epigallocatechin

Cat.No: T2987

Synonym: 表没食子儿茶素,(-)-表没食子儿茶素,l-Epigallocatechin,Epigallocatechin,EGC

Target: MMP, Autophagy

Cat.No: T3S0640

Synonym: 三油酸甘油酯,Glycerol trioleate,甘油三油酸酯,Glycerine Trioleate

Target: MMP, Others, Endogenous Metabolite

Apigenin-7-glucuronide

Cat.No: T5S1026

Synonym: Apigenin 7-O-glucuronide,芹菜素-7-葡萄糖醛酸

Target: MMP

Aloin(mixture of A&B)

Cat.No: T5680

Synonym: 芦荟素,葡糖基蒽酮,芦荟大黄素甙,芦荟苷

Target: MMP, IL Receptor, Antibacterial, Antifungal

Cat.No: T2750

Synonym: 银杏内酯C,BN-52022

Target: MMP, Sirtuin, Endogenous Metabolite, AMPK

Astragaloside IV

Cat.No: T2973

Synonym: AST-IV,黄芪甲苷IV,AS-IV,黄芪皂苷 IV

Target: MMP, ERK, Estrogen/progestogen Receptor, JNK

β-Anhydroicaritin

Cat.No: T6S2140

Synonym: Anhydroicaritin,Beta-Anhydroicaritin,脱水淫羊藿素

Target: MMP, Others, TNF, Interleukin

Cat.No: T1687

Synonym: Vibramycin,多西环素,Doxiciclina,Doxytetracycline,Doxycyclinum,强力霉素

Target: MMP, ribosome, Antibacterial, Antibiotic, Parasite

Luteolin 7-O-glucuronide

Cat.No: T3850

Synonym: Luteolin-7-glucuronide,木犀草素-7-O-葡萄糖醛酸苷

Target: MMP

Cat.No: T5S0045

Synonym: 6,8-Dimethoxyumbelliferone,异秦皮啶,Phytodolor,异嗪皮啶

Target: MMP, ERK, p38 MAPK, TLR, COX

Cat.No: T4S21320

Synonym: 异银杏素,4',4'''-Dimethylamentoflavone,异银杏双黄酮

Target: MMP, Others

20(R)-Ginsenoside Rh2

Cat.No: T3813

Synonym: 20(R)-人参皂苷 RH2,(20R)Ginsenoside Rh2,Ginsenoside Rh2,20(R)-人参皂苷Rh2

Target: Apoptosis, MMP, HSV

Chloramphenicol

Cat.No: T1205

Synonym: Chlornitromycin,Levomycetin,Chloromycetin,氯霉素

Target: ribosome, HIF/HIF Prolyl-Hydroxylase, Antibacterial, Antibiotic

Doxycycline (hyclate)

Cat.No: T1687L

Synonym: Doxycycline hydrochloride hemiethanolate hemihydrate,盐酸强力霉素,WC2031,Doxycycline hyclate

Target: MMP, ribosome, Antibacterial, Antibiotic

3-Aminopropionitrile fumarate (2:1)

Cat.No: T2769

Synonym: Di-β-aminopropionitrile fumarate,3-Aminopropionitrile fumarate,3-氨基丙腈,β-Aminopropionitrile fumarate,3-Aminopropionitrile fumarate 2:1,Beta-Aminopropionitrile fumarate,β-Ammoniumpropionitrile hemifumarate

Target: Others

2,3-Dihydrohinokiflavone

Cat.No: TN2697

Target: MMP, Parasite, Antifection

Cat.No: TN4088

Target: PAFR

Cat.No: TN4592

Target: IL Receptor, TNF, COX, Prostaglandin Receptor

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